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Keynote Lectures

Erik Meijering, Erasmus University Medical Center, Netherlands
          Title: Advances and Challenges in Dynamic Bioimage Analysis

Lionel Pazart, CHU, France
          Title: How to Cross the Border from R to D

Nuno Sousa, University of Minho, Portugal
          Title: Available Soon

David Rose, MIT Media Lab, United States
          Title: Available Soon



Advances and Challenges in Dynamic Bioimage Analysis

Erik Meijering
Erasmus University Medical Center

Brief Bio
Erik Meijering was born in Heemskerk, the Netherlands, in 1971. He received a MSc degree (cum laude) in Electrical Engineering from Delft University of Technology, the Netherlands, in 1996, and a PhD degree in Medical Imaging from Utrecht University, the Netherlands, in 2000.
From November 2000 to September 2002 he was with the Biomedical Imaging Group of the Swiss Federal Institute of Technology (EPFL) in Lausanne, Switzerland. In October 2002 he joined the Biomedical Imaging Group Rotterdam of the Erasmus MC - University Medical Center Rotterdam, as an Assistant Professor. In June 2008 he became an Associate Professor in the same group. His research interests include many aspects of computer vision, image processing and image analysis, and their applications in cellular and molecular imaging.
He received a Best Paper Award from the Computer Vision Research Foundation (the Netherlands) in 1999. In 2000 he received a TALENT-stipend from the Netherlands Organization for Scientific Research (NWO) for research on adaptive interpolation. Currently his main research subject is spatiotemporal modeling and segmentation of fluorescence microscopy images for the quantification and analysis of subcellular dynamical processes, for which he received a VIDI-grant from NWO for the period 2005-2010.
Dr. Meijering is a Senior Member of the Institute of Electrical and Electronics Engineers (IEEE), the IEEE Engineering in Medicine and Biology Society (EMBS), and the IEEE Signal Processing Society (SPS). From 1997 to 2008 he was a member of the International Association for Pattern Recognition (IAPR). He was Special Sessions Chair for the 2002 and the 2004 IEEE International Symposium on Biomedical Imaging (ISBI), and Technical Program Chair for that meeting in 2006 and 2010. He was/is an Associate Editor for the IEEE Transactions on Medical Imaging (since 2004), the IEEE Transactions on Image Processing (term 2008-2011), and the International Journal on Biomedical Imaging (2006-2009), and was a Guest Editor for the IEEE Transactions on Image Processing for its September 2005 Special Issue on Molecular and Cellular Bioimaging. He also served/serves in a great variety of conference, advisory, and review boards.

Available Soon



How to Cross the Border from R to D

Lionel Pazart

Brief Bio
Lionel Pazart is a French M.D. and has completed a Ph.D from Lille 2 University and postdoctoral studies from Brussels University School of Medicine (MPH). He is currently the director of Inserm CIT808 at Besancon University Hospital, a clinical research center dedicated to develop innovative technologies. He has published more than 35 papers in peer-review international journals, more than 100 communications and holds 10 patents.

Innovation in health care is hard, long and expensive. Many barriers impede quick harmonious and worthy development of new useful medical devices. Basic researcher rarely knows what discovery will serve and disruptive innovations in health mostly come from basic research whose authors have not suspected the consequences (for instance, the discovery of electron spin in 1922 to the MRI in 70’s). At the opposite, applied researcher is primarily concerned towards a specific practical objective (for instance non invasive biopsy of biological tissues). But the technology itself could constitute a high barrier because innovators’ tendency is to be infatuated with their own gadgets and blind to users’ needs and insurers’ acceptation.

Between these both enemies brothers, experimental development is a systematic work, using knowledge gained from basic research and/or practical experience, which is directed to produce new products or to improve substantially those already existing. The border between Research and Development for a new medical devices is often unclear since the process of development of a new medical device remains non linear, with the need of feedback from trials in clinical situation before finalisation of the product. More importantly, the classification of the different steps of a project impacts on 1/the identification of right partners for the project, 2/ state aid intensities, generally lower for activities linked to development than for research related activities 3/impact factor of publication related to the phase of the project. Sometimes basic researchers neglect these further studies because it is thought that, although essential to set-up innovative technologies, they do not lead to an increase of fundamental knowledge. However, and especially in the field of medical devices, users have to face specific difficulties due to the variability of the biological systems under study. In order to address these new challenges, reverse translational research is required. Fundamental research is then fed from the results of translational research. The lemniscal circonvolution model could help to better understand this trajectory from R to D.

In this overview, we would like to present an useful model of medical device development through several examples of translational research to illustrate the adequacy of research to bridging fundamental research results to the closest to the patients.

Keywords: Translational research, Medical Device, Innovation, Lemniscal circonvolution.



Keynote Lecture

Nuno Sousa
University of Minho

Brief Bio
Nuno Sousa (45 years-old, MD, PhD) is Full Professor at the School of Health Science,University of Minho. He is the Director of the Medical Degree at University ofMinho. He serves at several medical education and medical assessment advisoryboards.

He is a NeuroRadiologist. Presently, he is theDirector of the Clinical Academic Center at Hospital de Braga. He coordinatesand is involved in several national and international research projects.

He is the Coordinator of the Neuroscience ResearchDomain at ICVS/University of Minho. His research main interests are focused inthe establishment of functional and structural correlations mediated by stress andaging and its implications in cognition and in neuropsychiatric disorders. Detailed assessment of neuroplastic events, incorporation of newly generatedcells into neuronal networks, rearrangements of established dendritic andsynaptic contacts, combined with behavioural, neurochemical andelectrophysiogical, molecular biology and (epi)genetics correlates have beenestablished in his laboratory; the work from the lab covers from basic toclinical research and several modulatory interventions have also been describedin order to promote recovery of structure and function in neuronal tissues.

Nuno Sousa has published more than 150 peer-reviewed research articles. In addition to academic merits, Nuno Sousa serves on severalscience policy and advisory board positions, and as an Ad hoc reviewerfor various neuroscience journal and international funding organizations. He isEditor-in-Chief of Frontiers in Behavioral Neuroscience and Member of theEditorial Board of Molecular Neurodegeneration.

 Since May2011 Nuno Sousa is also the President of the Portuguese Society for Neuroscience.

Available Soon



Keynote Lecture

David Rose
MIT Media Lab
United States

Brief Bio
Product designer, teacher, and serial entrepreneur. Currently CEO at Vitality, a wireless health company that makes the award-winning GlowCap, the first Internet-connected medication packaging. David was co-founder and CEO of Ambient Devices where he created glanceable technology: embedding Internet information in everyday objects like light bulbs and umbrellas to make the physical objects an interface to digital information. David founded Viant’s Innovation Center, an advanced technology group for Fortune 500s including Sony, GM, Schwab, Sprint and Kinkos. He helped build Viant to over 900 people, $140M and a successful IPO.

In 1997 Rose patented online photo-sharing with Neil Mayle and founded Opholio (acquired by FlashPoint Technology).
Before the Internet he founded and was President of Interactive Factory (acquired by RDW Group) which still creates interactive museum exhibits, educational software and smart toys, including the award-winning LEGO Mindstorms Robotic Invention System.

David co-teaches a popular course in tangible user interfaces at the MIT Media Lab with Hiroshi Ishii. He is a frequent speaker to corporations and design and technology conferences. He received his BA in Physics from St. Olaf College, studied Interactive Cinema at the MIT Media Lab, and earned a Masters at Harvard.

Available Soon